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"Good" Cholesterol (HDL) can clear plaque
Study found Artery "Drano"
Lindsey Tanner
Associated Press - reported in C-Health News / Toronto Star
November 4, 2003
Protein reduces plaque buildup - research called a "breakthrough"
Intravenous doses of a synthetic component of "good" cholesterol reduced artery disease in just six weeks in a small study with startlingly big implications for North Amercia's No. 1 killer.
"The concept is a sort of liquid Drano for the coronary arteries," said Dr. Steven Nissen, a Cleveland Clinic cardiologist
who led the study published in today's Journal of the American Medical ssociation.
Larger and longer studies need to be done to determine if the experimental treatment will translate into fewer deaths, but the early results are promising, said Dr.
Daniel Rader, director of preventive cardiology at the University of Pennsylvania School of Medicine.
The treatment used a laboratory-produced version of an unusually effective form of HDL, the good cholesterol that helps protect against heart disease by removing plaque, or fatty build-ups, from the bloodstream.
"This is clearly on the level of a breakthrough that will have far reaching implications," pointing the way toward a rapid treatment for fatty buildups, said Dr. Bryan Brewer, chief of molecular diseases at the National Heart, Lung and Blood Institute.
The surprising quick results, though preliminary, shatter a long-standing belief that heart disease is a slow-progressing disease that takes a long time to undo, said Rader.
While some existing medicines target HDL, most conventional drug treatments work by reducing levels of LDL cholesterol, the bad kind that contributes to the formation of plaques
that can clog arteries and lead to heart attacks. Nissen's study is part of a burgeoning area of research that focuses on treatments that raise HDL levels or improve HDL's
plaque-fighting abilities.
In the study, scientists made a synthetic form of the protein that makes larger-than-normal HDL particles, believed to make HDL cholesterol especially efficient at removing plaque.
The synthetic protein was found to reduce plaque buildups rapidly in mice and rabbits.
The product was first tested and shown to be safe for use in humans. This latest round of experiments is the first time the substance has been used to actually treat narrowing of
the arteries in people. The study was funded by Esperion Therapeutic Inc. Of Ann Arbor, Mich., a small biotechnology company that makes the product.
At six weeks, imaging tests showed the patients receiving the synthetic protein had a visible 4 per cent reduction in plaque buildup in their coronary arteries. There was no significant change in the placebo group.
Rader called the results "surprising to even the most optimistic supporters" of using HDL to treat narrowing of the arteries. Commercial use is probably a few years off.
"Plaque buildup" Treatment Strategy
No need to wait! Get Good Cholesterol or HDL from a nutritional therapy comprising of RBO
Back to Diabetes - Heart Diseases
The above information is provided for general
educational purposes only. It is not intended to replace competent
health care advice received from a knowledgeable healthcare professional.
You are urged to seek healthcare advice for the treatment of any
illness or disease.
Health Canada and the FDA (USA) have not evaluated these
statements. This product is not intended to diagnose, treat, cure, or prevent
any disease.
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